Death, Heartbreak and a Whole Lot of Sex: Inside Grey’s Anatomy’s Groundbreaking 15-Year Reign

15 seasons is a lot of television.

By the time Grey's Anatomy embarks on its landmark season with a two-hour premiere on Thursday, Sept.

27, it will have already aired 317 hours of television.

It will have weathered the departure of 17 different series regulars, spawned two successful spinoffs, given rise to a powerhouse production company, launched countless careers, pulled itself through fallow storytelling periods, found a new legion of fans via Netflix, aired under the backdrop of three different American presidencies, and become an institution that just might be responsible for keeping ABC afloat.

It is the longest-running scripted primetime series currently airing on its network,...

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